I noticed that elevators take a lot longer than the shuttle-thing in the Citadel to zone. It also stops loading when you mess around in the menus - can't even read the journal and such during the ride
Still the best game I've ever played so far - only got it today and I'm still in the Citadel. Definitely going to have to play it again when I'm done. I have as many points in charm as I can get, but there are still some dialog options grayed out in the main story.
I do wonder if Vanguards are a little weak though, not impressed with my bionic powers at all. Probably should have picked a soldier =/
btw: surprised nobody mentioned that the strippers in the club show their nipples

No outrage and no AO rating, I'm impressed!